Tayebeh Dehghan; Amirhossein Asadi; Zahra Sohrabi; Marzieh Akbarzadeh; Kimia Leilami
Abstract
Background: Obesity and non-alcoholic fatty liver disease (NAFLD) are considered as the main causes of liver-associatedmorbidity and mortality. Antioxidant administration was proposed as a remedy for liver problems such as steatohepatitis. This systematic review aimed to examine the effects of supplementation ...
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Background: Obesity and non-alcoholic fatty liver disease (NAFLD) are considered as the main causes of liver-associatedmorbidity and mortality. Antioxidant administration was proposed as a remedy for liver problems such as steatohepatitis. This systematic review aimed to examine the effects of supplementation with various forms of Vitamin E on liver enzymes.Methods: To find relevant articles, in our systematic review article, we searched PubMed, Scopus, Embase, Cochrane library, and Web of Science up to 20 MAY, 2021. Randomized controlled trials (RCTs) on the effects of vitamin E supplementation, in isolation or combined with other nutrients, on liver health were included. After excluding irrelevant records, 21 studies remained.Results: According to the results of the included studies, vitamin E, especially α-Tocopherol or its co-supplementation with other antioxidants, at specific dosage could possibly have positive effects on improving liver functions and levels of Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymes.Conclusion: Vitamin E,could possibly have positive effects on improving the liver function and the levels of ALT and AST enzymes.
Nasrin Nasimi; Mohammad Hossein Dabbaghmanesgh; Mohammad Fararooei; Amirhossein Asadi; Marzieh Akbarzadeh; Zahra Sohrabi
Abstract
Background: Sarcopenia, an age-related decline in muscle mass, strength, and function, contributes to various adverse health outcomes and physical impairments. This study aimed to investigate the association between sarcopenia components and health-related quality of life (HRQoL) among communitydwelling ...
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Background: Sarcopenia, an age-related decline in muscle mass, strength, and function, contributes to various adverse health outcomes and physical impairments. This study aimed to investigate the association between sarcopenia components and health-related quality of life (HRQoL) among communitydwelling older adults.Methods: In this cross-sectional study, 501 adults aged 65 years or older participated. Sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia (AWGS) guideline. Muscle mass was measured by bioelectrical impedance analysis (BIA), muscle strength by hand dynamometer, and physical function by 4-m gait speed. The HRQoL was assessed using 12 item shortform healthy survey (SF-12) questionnaire.Results: There was a significant relationship between the sarcopenia and demographic characteristics (educational levels and smoking habits). After adjustment for age, sex, Body Mass Index, education level, smoking habits, and number of comorbidities, a significant relationship was observed between sarcopenia and physical components of HRQoL. According to multivariate linear regression, low muscle mass was negatively related to physical aspects of HRQoL. Low handgrip strength (HGS) and gait speed (GS) were inversely correlated to both physical and mental components of HRQoL.Conclusion: Our study highlighted the adverse impact of sarcopenia on HRQoL in elderly population. Reduction in muscle strength and physical performance not only affected physical aspects but also were linked with mental components of HRQoL. Therefore, it seems HGS and GS might be good indicators affecting all aspects of HRQoL in the elderly groups.